The news agency said the airstrike hit a hospital, among other sites. Six people were killed and 10 others wounded.
This is the fourth air raid of the coalition in Deir ez-Zor over the month, according to SANA.
On Saturday, SANA reported that the coalition, which ostensibly fights Daesh, hit houses in al-Mayadeen, killing 10, including five children.
The US-led coalition of 68 nations started to carry out airstrikes against Daesh in Syria and Iraq in 2014, with the strikes in Syria not being authorized by the government of President Bashar Assad or the UN Security Council.